The “Second Case” of AIDS Patients in the World Was Cured, Can “ART” Be Replaced?

2020-03-05
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(Summary description)AccordingtoSinaTechnology,SurgingNewsandmanyothermediareports,onMarch10,thetopmedicaljournal"LancetHIV"(LancetHIV)publishedthelatestresultsofRavindraKumarGuptaandotherprofessorsattheUniversityofCambridgeMedicalFaculty.　　Amongthem,thethesispointsoutthatthe“Londonpatient”cannotdetectHIVintheblood,becomingthesecondAIDSpatientintheworldtobe“cured”.　　LikethefirstBerlinpatienttobesuccessfullycuredintheworld,healsoreceivedabonemarrowmatchingtransplantwithaCCR5-Δ32mutation.Therefore,thepaperprovesonceagainthepossibilityofusingCCR5mutanthematopoieticstemcelltransplantationtotreatAIDS.　　Nodoubt,thisisexcitingnews,anditalsogiveshopetocountlessHIVpatients,especiallychildrenaffectedbymother-to-childtransmission.　　Inaddition,oncethisnewswasannounced,manyfollowersexpressedtheiropinions.OneofthenetizensconcludedthatthetherapyistochangethestructureofCCR5expressedaftermutatingtheCCR5genetotheCCR5-△32gene,hinderingtherecognitionofHIVandTcells.combinewith.HIVrecognizesTcellsbybindingacertainproteinonthesurfaceofthevirustoreceptorsonthesurfaceofTcells,andundertheactionofCCR5,toinfectthecells.VeryfewpeoplehaveCCR5-△32homozygousmutationTcells,thusCanreducetheriskofHIVinfection.　　Regardlessofwhetherthestatementiscorrectornot,fromtheperspectiveofitsobjectiveandpositiveremarks,weshouldallimitateit.However,duetothedifferentknowledgeandlevelofvarioussocialstrata,wehaveunknowinglygraduallystartedallkindsofscoldingaroundthetopic.war!

The “Second Case” of AIDS Patients in the World Was Cured, Can “ART” Be Replaced?

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The “Second Case” of AIDS Patients in the World Was Cured, Can “ART” Be Replaced?

(Summary description)AccordingtoSinaTechnology,SurgingNewsandmanyothermediareports,onMarch10,thetopmedicaljournal"LancetHIV"(LancetHIV)publishedthelatestresultsofRavindraKumarGuptaandotherprofessorsattheUniversityofCambridgeMedicalFaculty.　　Amongthem,thethesispointsoutthatthe“Londonpatient”cannotdetectHIVintheblood,becomingthesecondAIDSpatientintheworldtobe“cured”.　　LikethefirstBerlinpatienttobesuccessfullycuredintheworld,healsoreceivedabonemarrowmatchingtransplantwithaCCR5-Δ32mutation.Therefore,thepaperprovesonceagainthepossibilityofusingCCR5mutanthematopoieticstemcelltransplantationtotreatAIDS.　　Nodoubt,thisisexcitingnews,anditalsogiveshopetocountlessHIVpatients,especiallychildrenaffectedbymother-to-childtransmission.　　Inaddition,oncethisnewswasannounced,manyfollowersexpressedtheiropinions.OneofthenetizensconcludedthatthetherapyistochangethestructureofCCR5expressedaftermutatingtheCCR5genetotheCCR5-△32gene,hinderingtherecognitionofHIVandTcells.combinewith.HIVrecognizesTcellsbybindingacertainproteinonthesurfaceofthevirustoreceptorsonthesurfaceofTcells,andundertheactionofCCR5,toinfectthecells.VeryfewpeoplehaveCCR5-△32homozygousmutationTcells,thusCanreducetheriskofHIVinfection.　　Regardlessofwhetherthestatementiscorrectornot,fromtheperspectiveofitsobjectiveandpositiveremarks,weshouldallimitateit.However,duetothedifferentknowledgeandlevelofvarioussocialstrata,wehaveunknowinglygraduallystartedallkindsofscoldingaroundthetopic.war!

Medical conference
2020-03-05 15:27
Views:

　　According to Sina Technology, Surging News and many other media reports, on March 10, the top medical journal "LancetHIV" (LancetHIV) published the latest results of RavindraKumarGupta and other professors at the University of Cambridge Medical Faculty.

　　Among them, the thesis points out that the “London patient” cannot detect HIV in the blood, becoming the second AIDS patient in the world to be “cured”.

　　Like the first Berlin patient to be successfully cured in the world, he also received a bone marrow matching transplant with a CCR5-Δ32 mutation. Therefore, the paper proves once again the possibility of using CCR5 mutant hematopoietic stem cell transplantation to treat AIDS.

　　No doubt, this is exciting news, and it also gives hope to countless HIV patients, especially children affected by mother-to-child transmission.

　　In addition, once this news was announced, many followers expressed their opinions. One of the netizens concluded that the therapy is to change the structure of CCR5 expressed after mutating the CCR5 gene to the CCR5- △ 32 gene, hindering the recognition of HIV and T cells. combine with. HIV recognizes T cells by binding a certain protein on the surface of the virus to receptors on the surface of T cells, and under the action of CCR5, to infect the cells. Very few people have CCR5- △ 32 homozygous mutation T cells, thus Can reduce the risk of HIV infection.

　　Regardless of whether the statement is correct or not, from the perspective of its objective and positive remarks, we should all imitate it. However, due to the different knowledge and level of various social strata, we have unknowingly gradually started all kinds of scolding around the topic. war!

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